… the PK of oral and IV midazolam. Inclusion of IIV for clearance, volume of distribution, and …
bioavailability 3 than found in our patients, and vice versa for preterm neonates. Statistically …

… to predict the disposition of IV Midazolam in preterm neonates of different gestational ages,
… Clinical pharmacology and therapeutic drug monitoring in neonates and children. Pediatr. …

… individual differences exist in pharmacokinetic parameters for intravenous midazolam. …
in preterm neonates compared with that in older infants and children. Midazolam undergoes …

… preterm infants were undertaken for tracheal intubation following the use of atropine associated
to either midazolam … pain was assessed using premature infant pain profile (PIPP) score. …

… and pharmacodynamics (including toxicity) in preterm neonates … midazolam concentration–time
profiles in preterm neonates … preterm neonates following a a 15 mg/kg single intravenous …

… In preterm neonates, overall expression of UGT appeared to be around 10% of that in adults.…
in this study, using an expanded intravenous midazolam dataset in pediatrics, indicated that …

… time after intravenous induction is slower in neonates that in … very preterm infants, partially
useful in older preterm infants, … and effect in a neonate given protocol midazolam bolus (0.1 …

… or extracorporeal life support, preterm infants, infants who need a … Intravenous continuous
infusions may be indicated when … on midazolam (MID) use in spontaneously breathing infants, …

… focus on pharmacokinetic and pharmacodynamic issues [3]. … a whole-body parent-metabolite
intravenous PBPK model of … in the Open Systems Pharmacology (OSP) repository as …

… be well-versed with the principles of pharmacology, drug dosages… for use in neonates and
none for preterm neonates born before 30 … Intravenous use can lead to hypotension and is not …